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Metabolism

Ketogenic diet

DEKetogene Ernährung

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The ketogenic diet is a very-low-carbohydrate (typically <50 g/day), high-fat, moderate-protein eating pattern that drives the body into sustained nutritional ketosis. Originally developed to treat refractory pediatric epilepsy, it is now studied for type 2 diabetes, obesity, and neurodegenerative conditions. Mechanisms include lower insulin, improved metabolic flexibility, and ketone-mediated signaling. Long-term effects on lipid profiles, kidney function, and adherence remain under active investigation.

Sources

  1. Paoli A, Rubini A, Volek JS, Grimaldi KA. (2013). Beyond Weight Loss: A Review of the Therapeutic Uses of Very-Low-Carbohydrate (Ketogenic) Diets. *European Journal of Clinical Nutrition*doi:10.1038/ejcn.2013.116
  2. Puchalska P, Crawford PA. (2017). Multi-Dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics. *Cell Metabolism*doi:10.1016/j.cmet.2016.12.022