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Metabolism

Intermittent fasting

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Intermittent fasting is an umbrella term for eating patterns that alternate normal intake with extended fasting windows, including 16:8 time-restricted eating, alternate-day fasting, and 5:2 protocols. Fasting periods lower insulin and glycogen, trigger lipolysis and ketogenesis, and induce autophagy. Clinical trials show modest improvements in body composition, glycemic control, and blood pressure; meta-analyses suggest results are broadly comparable to matched continuous calorie reduction, though some trials report small advantages for visceral fat or insulin sensitivity.

Sources

  1. Longo VD, Mattson MP. (2014). Fasting: Molecular Mechanisms and Clinical Applications. *Cell Metabolism*doi:10.1016/j.cmet.2013.12.008
  2. Trepanowski JF, Kroeger CM, Barnosky A, Klempel MC, Bhutani S, Hoddy KK, et al.. (2017). Effect of Alternate-Day Fasting on Weight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults. *JAMA Internal Medicine*doi:10.1001/jamainternmed.2017.0936