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Nutrition & supplements

Resveratrol

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Resveratrol is a stilbene polyphenol found in grape skins, red wine, and Japanese knotweed. It is studied as a putative sirtuin (SIRT1) activator and AMPK modulator, with effects on inflammation and mitochondrial function in preclinical models. Human trials have produced inconsistent results, and oral bioavailability is poor. There is currently no robust evidence that resveratrol supplementation extends human lifespan or healthspan.

Sources

  1. Howitz KT, Bitterman KJ, Cohen HY, et al.. (2003). Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. *Nature*doi:10.1038/nature01960
  2. Baur JA, Pearson KJ, Price NL, et al.. (2006). Resveratrol improves health and survival of mice on a high-calorie diet. *Nature*doi:10.1038/nature05354