Fisetin
Fisetin is a flavonoid (a plant compound) found in strawberries, apples, and persimmons. So you already eat a little. In aged mice, one study (Yousefzadeh et al., 2018, EBioMedicine) gave it late in life, on and off. The mice cleared more senescent ('zombie') cells, lived longer on average, and had healthier tissue. But a tougher test did not agree. The NIA testing program (Harrison et al., 2023) tried fisetin in genetically diverse mice and saw no lifespan gain in either sex. And early human trials have not shown it clears senescent cells. So treat the 'senolytic' claim as unproven for now. The idea is that it kills senescent cells and calms inflammation, which makes it a candidate diet senolytic. Trials in people are ongoing, and the evidence is still early.
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Sources
- Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, et al.. (2018). Fisetin is a senotherapeutic that extends health and lifespan. *EBioMedicine*doi:10.1016/j.ebiom.2018.09.015
- Harrison DE, Strong R, Reifsnyder P, et al.. (2023). Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan. *GeroScience*doi:10.1007/s11357-023-01011-0