Fisetin
Reviewed by Maurice Lichtenberg
Fisetin is a flavonoid found in strawberries, apples, and persimmons. In aged mice, Yousefzadeh et al. (2018, EBioMedicine) reported reduced senescent cell burden and extended median lifespan using a late-life intermittent dosing protocol; the paper also documented reduced age-associated tissue dysfunction. Independent replication remains limited. Mechanisms include induction of apoptosis in senescent cells and modulation of inflammatory pathways, making it a candidate dietary senolytic under investigation. Human trials are ongoing, and clinical evidence in people remains preliminary.