New Aging Clocks Reveal Blood Clotting Factors May Drive Organ Decline

Based on: Multimodal clocks of human aging.

Moderate Evidence·Journal Article·Cell·May 2026

Researchers built a multi-layered aging clock using clinical, physiological, and molecular data from over 2,000 Chinese adults. They found that plasma proteins can predict both your age and how well your body is holding up. The standout discovery: clotting factors pile up with age and may fuel organ-wide aging and inflammation.

Key Insight

This research points to blood-based protein tests as a promising way to track biological age in the future.

Original Paper

Li J, Jiang B, Zhang W, Hao J, Liu Z, Ji Q, Zheng Y, Lu X, Zheng Z, Ma S, Fan Y, Gao DD, Hou XW, Li J, Tang J, Jing Y, Geng L, Wu R, Zhang B, Sun S, Cai Y, Yan K, Xiong M, Dong C, Ma X, Xu G, Ji Z, Yan H, Zheng Q, Huang H, Zhang L, Li J, Jiang M, Xu LJ, Chen Y, Qu G, Lei W, Wang H, Ping J, Zhou J, Yi M, Jiang M, Jing Y, Ye WD, Zhang X, Chu X, He Y, Zhao Q, Wu Q, He M, Ma L, Liu P, Zhao L, Zhai QC, Qin J, Lu J, Yang X, Zhang S, Xiong Y, Ren H, Yang W, Huang Z, Zhang J, Zhang M, Chen P, Dong J, Zhang Y, Yan T, Ye JL, Huang P, Qi Z, Liu Y, Shuai J, Chen CS, Li P, Li D, Xu X, Song X, Li J, Ping J, Hu J, Sun X, Ai J, Wang Z, Zhang Y, Yang P, Ning T, Yu Y, He Z, Zhang H, Zhang T, Yang Y, Wang Q, Lin F, Jin X, Chen X, Ren J, Song M, Wang S, Yang J, Li J, Song W, He F, Yang YG, Pei G, Qu J, Zhang W, Pu J, Zhang F, Zhao G, Zhang W, Liu GH

Cell··2,019 Chinese adults aged 18-91

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Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.