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Sleep & circadian

Sleep pressure / two-process model

DESchlafdruck / Zwei-Prozess-Modell

The two-process model, proposed by Alexander Borbély in 1982, explains sleep and wake as two forces working together. Process S is homeostatic sleep pressure. It builds up while you are awake, as adenosine and other sleep signals pile up, and it drains away while you sleep. Process C is the circadian signal, made by your suprachiasmatic nucleus. It runs on a roughly 24-hour cycle and pushes alertness up toward evening, fighting the rising sleep pressure so you stay awake. You fall asleep when Process S grows past the circadian alerting threshold. The model neatly explains the post-lunch dip, the rebound deep sleep after a missed night, and the sharp wake-up boundary in the morning. It is still the leading framework for sleep and circadian research.

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Sources

  1. Borbély AA. (1982). A two process model of sleep regulation. *Human Neurobiology*
  2. Borbély AA, Daan S, Wirz-Justice A, Deboer T. (2016). The two-process model of sleep regulation: a reappraisal. *Journal of Sleep Research*doi:10.1111/jsr.12371