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Sleep & circadian

Circadian rhythm

DEZirkadianer Rhythmus

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The circadian rhythm is the body's roughly 24-hour internal cycle that coordinates sleep-wake timing, hormone release, body temperature, and metabolism. It is governed by the suprachiasmatic nucleus in the hypothalamus and entrained primarily by light exposure. Stable circadian alignment supports cardiometabolic health, immune function, and cognitive performance, while chronic disruption is linked to obesity, type 2 diabetes, and accelerated biological aging.

Sources

  1. Konopka RJ, Benzer S. (1971). Clock Mutants of Drosophila melanogaster. *Proceedings of the National Academy of Sciences USA*doi:10.1073/pnas.68.9.2112
  2. Fagiani F, Di Marino D, Romagnoli A, Travelli C, Voltan D, Di Cesare Mannelli L, Racchi M, Govoni S, Lanni C. (2022). Molecular regulations of circadian rhythm and implications for physiology and diseases. *Signal Transduction and Targeted Therapy*doi:10.1038/s41392-022-00899-y