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Therapeutics

Plasmapheresis

DEPlasmapherese

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Plasmapheresis is the umbrella term for extracorporeal procedures that separate plasma from cellular blood components; technique varies, with plasma either fractionated or filtered and partially returned, or wholly removed and replaced as in TPE. It is established for autoimmune and hyperviscosity disorders, where its dominant mechanism is removal of pathogenic plasma factors such as antibodies, immune complexes, and inflammatory mediators. In longevity contexts it is proposed to dilute pro-aging plasma factors, but evidence for healthy-aging benefit is preliminary.

Sources

  1. Kim D, Kiprov DD, Luellen C et al.. (2022). Old plasma dilution reduces human biological age: a clinical study. *GeroScience*doi:10.1007/s11357-022-00645-w
  2. Mehdipour M, Etienne J, Liu C, Mehdipour T, Kato C, Conboy M, Conboy I, Kiprov DD. (2021). Attenuation of age-elevated blood factors by repositioning plasmapheresis: A novel perspective and approach. *Transfusion and Apheresis Science*doi:10.1016/j.transci.2021.103162