Lp(a) (Lipoprotein(a))

Lipoprotein(a), or Lp(a), is an LDL-like particle. In it, apolipoprotein(a) is covalently linked to apoB-100 through a disulfide bond. Your plasma level is largely genetic (often cited around 70 to 90%) and usually stable across adulthood, though it can shift modestly with menopause, kidney disease, or inflammation. Mendelian randomization at the LPA gene supports a causal role for high Lp(a) in heart attack, ischemic stroke, and calcific aortic valve narrowing. Because diet and lifestyle barely move it, you should measure Lp(a) at least once, to gauge your lifetime cardiovascular risk. Per the EAS 2022 thresholds, a rule-in risk level is above 50 mg/dL (above 125 nmol/L), and a rule-out level is below 30 mg/dL (below 75 nmol/L).

Last reviewed: June 22, 2026

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