ApoB

Apolipoprotein B (ApoB) is the backbone protein of the 'bad' lipoproteins that clog arteries. These include LDL, VLDL, IDL, and Lp(a). Each such particle carries about one ApoB-100. So your ApoB level acts as a head-count of your artery-clogging particles. Gene studies (Mendelian randomization, e.g. Richardson et al.) flag ApoB and particle number as the true causal driver of coronary artery disease. That makes ApoB a sharper predictor of heart attacks and death than LDL cholesterol alone. The lower your ApoB, the less artery disease you tend to have. The NLA expert consensus sets common targets. Aim below 90 mg/dL at moderate risk. Aim below 70 mg/dL at high risk. And aim below 60 mg/dL at very high risk.

Last reviewed: June 22, 2026

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