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Aging clocks

PCGrimAge

PCGrimAge applies the same noise-reduction trick to the GrimAge clock. (The trick comes from Higgins-Chen et al., 2022.) The result is a more technically stable version of one of the strongest death-predicting epigenetic clocks. It works by statistically removing array-platform and batch noise before scoring. That makes PCGrimAge much more reproducible within one person than the original GrimAge (Lu et al. 2019). That matters a lot when you track biological-age change over time. The change might come from caloric restriction, exercise, or drugs. Like PCPhenoAge, it is a methodological upgrade, not a new biological model.

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Sources

  1. Higgins-Chen AT, Thrush KL, Wang Y, Minteer CJ, Kuo PL, Wang M, Niimi P, Sturm G, Lin J, Moore AZ, Bandinelli S, Vinkers CH, Vermetten E, Rutten BPF, Geuze E, Okhuijsen-Pfeifer C, van der Horst MZ, Schreiter S, Gutwinski S, Luykx JJ, Picard M, Ferrucci L, Poganik JR, Bhanu NV, Garcia BA, Horvath S, Raj K, Levine ME. (2022). A computational solution for bolstering reliability of epigenetic clocks: implications for clinical trials and longitudinal tracking. *Nature Aging*doi:10.1038/s43587-022-00248-2