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Cell biology

Oxidative stress

DEOxidativer Stress

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Oxidative stress is an imbalance between reactive oxygen species production and the body's antioxidant defences, leading to oxidative damage of biomolecules. It impairs mitochondrial function, accelerates telomere attrition, and drives chronic low-grade inflammation. Implicated in many hallmarks of ageing, oxidative stress is associated with cardiovascular disease, neurodegeneration, diabetes, and cancer, and is modulated by diet, exercise, sleep, and environmental exposures.

Sources

  1. Liguori I, Russo G, Curcio F, et al.. (2018). Oxidative stress, aging, and diseases. *Clinical Interventions in Aging*doi:10.2147/CIA.S158513
  2. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. (2007). Free radicals and antioxidants in normal physiological functions and human disease. *International Journal of Biochemistry & Cell Biology*doi:10.1016/j.biocel.2006.07.001
  3. Butterfield DA, Halliwell B. (2019). Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease. *Nature Reviews Neuroscience*doi:10.1038/s41583-019-0132-6