Loss of proteostasis
DEVerlust der Proteostase
Loss of proteostasis is one of the established hallmarks of aging. The word 'proteostasis' means protein balance. This hallmark is the age-related decline of your protein quality-control network. Three things slip. Your chaperones (the folding helpers) get less efficient. Your proteasome and autophagy (the disposal systems) slow down. And misfolded, sticky proteins pile up. The resulting protein toxicity feeds disease. That includes brain disorders, heart amyloidosis, and cell trouble across tissues. That is why drugs to restore protein balance are an active longevity target.
Last reviewed:
This definition is educational and is not medical advice, a diagnosis, or treatment. Talk to a doctor about any health decisions. Read our full medical disclaimer