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Cell biology

iPSCs (induced pluripotent stem cells)

DEiPSC (induzierte pluripotente Stammzellen)

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Induced pluripotent stem cells (iPSCs) are adult somatic cells reprogrammed into a pluripotent state using factors such as OSKM (Oct4, Sox2, Klf4, c-Myc), capable of differentiating into any cell type of the body. They bypass the ethical concerns of embryonic stem cells and enable patient-specific disease modeling, drug screening, and autologous cell therapies. In aging research, iPSCs reset many epigenetic age markers, though epigenetic resetting is often incomplete and iPSCs can retain partial donor-cell epigenetic memory, providing a powerful platform to study and reverse cellular aging.

Sources

  1. Takahashi K, Yamanaka S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. *Cell*doi:10.1016/j.cell.2006.07.024
  2. Takahashi K, Tanabe K, Ohnuki M, et al.. (2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. *Cell*doi:10.1016/j.cell.2007.11.019