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Cell biology

Insulin/IGF-1 pathway

DEInsulin/IGF-1-Signalweg

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The insulin/IGF-1 pathway (often abbreviated IIS) is a conserved nutrient-sensing network in which insulin and IGF-1 bind tyrosine kinase receptors to activate PI3K, AKT, and mTOR while inhibiting FOXO. It coordinates glucose uptake, growth, and anabolic metabolism with nutrient availability. Loss-of-function mutations along this pathway dramatically extend lifespan in C. elegans (daf-2), Drosophila, and mice, establishing IIS as a foundational longevity pathway across the animal kingdom.

Sources

  1. Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R. (1993). A C. elegans mutant that lives twice as long as wild type. *Nature*doi:10.1038/366461a0
  2. Taguchi A, White MF. (2008). Insulin-like signaling, nutrient homeostasis, and life span. *Annual Review of Physiology*doi:10.1146/annurev.physiol.70.113006.100533