iAge (immune age clock)
DEiAge (Immunalteruhr)
iAge is an 'inflammatory age' score, introduced by Sayed and colleagues (2021, Stanford). It uses a deep-learning model, trained on a panel of 50 blood cytokines and chemokines, from 1,001 healthy people in the decade-long Stanford 1000 Immunomes Project. The model compresses your immune profile into a single inflammatory-age score. That score predicts heart risk, multiple-disease burden, and death from all causes, independent of your calendar age. The single most informative driver was a chemokine called CXCL9, linked to T-cell recruitment and blood-vessel dysfunction. The clock highlights your immune system as a distinct, targetable dimension of aging.
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