Extracellular matrix (ECM) aging
DEAlterung der extrazellulären Matrix (EZM)
The extracellular matrix (ECM) is the protein-and-sugar scaffold that holds your tissues together. It also passes chemical and mechanical signals to the cells living in it. As you age, this scaffold stiffens, frays, and changes its makeup. Several things drive that: built-up crosslinks, sugar-damage products (glycation), slower matrix turnover, and an out-of-balance set of remodeling enzymes (MMPs) and their inhibitors (TIMPs). A stiffer ECM changes how cells read their surroundings (through integrins). It also pushes pro-scarring TGF-beta pathways. And it reinforces the inflammatory SASP of senescent cells in a self-feeding loop. All of this slows tissue repair, degrades stem-cell niches, and feeds problems like heart fibrosis, osteoarthritis, and age-related lung decline. That is why keeping the ECM healthy is an emerging longevity target.
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Sources
- Rozario & DeSimone. (2010). The extracellular matrix in development and morphogenesis: A dynamic view. *Developmental Biology*doi:10.1016/j.ydbio.2009.10.026
- Herrera J, Henke CA, Bitterman PB. (2018). The extracellular matrix as a driver of progressive fibrosis. *Journal of Clinical Investigation*doi:10.1172/jci93557