What is the Longevity Research Library?

The Longevity Switzerland Research Library curates recent peer-reviewed studies on longevity, nutrition, exercise, sleep, and supplements. Each study is rated by evidence strength: Strong, Moderate, or Preliminary.

How are evidence levels determined?

Evidence levels are based on study type (meta-analysis, RCT, cohort study), sample size, journal impact factor, and reproducibility of findings.

79 studies

Research Library

Peer-reviewed papers from top journals, summarized and graded by evidence strength. Updated Mon, Wed & Fri.

6/79

Apr 12–18, 2026

Quail Bred to Reproduce More Aged Faster, Supporting a Core Theory of Aging

Researchers selectively bred Japanese quail for higher or lower reproductive effort across several generations. By generations five and six, the high-reproduction birds died sooner. The lifespan difference came from faster aging rates, not from being more fragile to begin with. This is some of the cleanest experimental evidence in vertebrates that investing more in reproduction comes at a real cost to longevity.

Proceedings. Biological sciences·Moderate·Apr 15, 2026

Mar 22–28, 2026

Fat Tissue Controls Lifespan Through Insulin Signaling in Fruit Flies

In fruit flies, dialing down a gene called Dicer-1 in fat tissue extended lifespan. It worked even when flies were already on calorie restriction. The mechanism involves a chain reaction: lower Dicer-1 reduces a small RNA molecule in fat, which boosts a hormone that then tells the brain to release less insulin. Less insulin signaling is a well-known longevity pathway across species.

Proceedings of the National Academy of Sciences of the United States of America·Preliminary·Mar 24, 2026

Mar 15–21, 2026

Eight Hyped Compounds Failed to Extend Lifespan in a Major Mouse Study

The NIA's Interventions Testing Program tested eight compounds across three lab sites in genetically diverse mice. None extended lifespan. That includes astaxanthin, alpha-ketoglutarate, pioglitazone, atorvastatin-telmisartan, and others with prior promising results. Some compounds previously shown to work at different doses or start ages didn't replicate under new conditions. Two drugs actually shortened lifespan in female mice.

GeroScience·Strong·Mar 17, 2026

Mar 8–14, 2026

Fish That Age Fast Reveal Predictable 'Life Stages' in Aging

Scientists tracked African killifish behavior continuously from adolescence to death. Long-lived fish behaved differently from short-lived ones surprisingly early in life. Machine learning could actually predict how long an individual fish would live based on its young-adult behavior alone. Aging didn't happen as a smooth decline. Instead, fish moved through distinct, stable behavioral stages separated by abrupt transitions.

Science (New York, N.Y.)·Preliminary·Mar 12, 2026

Vitamin C May Slow Primate Aging by Blocking Iron-Driven Cell Damage

As primates age, iron builds up in tissues and fuels a chain reaction of fat damage in cells. Researchers call this process "ferro-aging" and found that a specific enzyme (ACSL4) drives it. When aged monkeys received vitamin C for over 40 months, it directly blocked that enzyme. The result was reduced tissue damage, better brain and metabolic function, and biological age clocks that ticked backward across multiple organs.

Cell metabolism·Moderate·Mar 11, 2026

A Newly Found Enzyme Breaks Down NAD+ Inside Mitochondria

Scientists identified a mitochondrial enzyme called SelO that breaks NAD+ into NMN and AMP. This reaction ramps up when mitochondria are working hard, essentially acting as a brake to prevent metabolic overload. It also plays a direct role in fat burning by linking up with fat oxidation enzymes. The mechanism is conserved from bacteria to mammals, suggesting it's been essential for a very long time.

Cell·Preliminary·Mar 9, 2026

Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.

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